Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

SummaryAging of immune organs, termed as immunosenescence, is suspected to promote systemic inflammation and age-associated disease. The cause of immunosenescence and how it promotes disease, however, has remained unclear. We report that the Drosophila fat body, a major immune organ, undergoes immunosenescence and mounts strong systemic inflammation that leads to deregulation of immune deficiency (IMD) signaling in the midgut of old animals. Inflamed old fat bodies secrete circulating peptidoglycan recognition proteins that repress IMD activity in the midgut, thereby promoting gut hyperplasia. Further, fat body immunosenecence is caused by age-associated lamin-B reduction specifically in fat body cells, which then contributes to heterochromatin loss and derepression of genes involved in immune responses. As lamin-associated heterochromatin domains are enriched for genes involved in immune response in both Drosophila and mammalian cells, our findings may provide insights into the cause and consequence of immunosenescence during mammalian aging.PaperFlic

Deformable Groupwise Registration Using a Locally Low-Rank Dissimilarity Metric for Myocardial Strain Estimation from Cardiac Cine MRI Images

Objective: Cardiovascular magnetic resonance-feature tracking (CMR-FT) represents a group of methods for myocardial strain estimation from cardiac cine MRI images. Established CMR-FT methods are mainly based on optical flow or pairwise registration. However, these methods suffer from either inaccurate estimation of large motion or drift effect caused by accumulative tracking errors. In this work, we propose a deformable groupwise registration method using a locally low-rank (LLR) dissimilarity metric for CMR-FT. Methods: The proposed method (Groupwise-LLR) tracks the feature points by a groupwise registration-based two-step strategy. Unlike the globally low-rank (GLR) dissimilarity metric, the proposed LLR metric imposes low-rankness on local image patches rather than the whole image. We quantitatively compared Groupwise-LLR with the Farneback optical flow, a pairwise registration method, and a GLR-based groupwise registration method on simulated and in vivo datasets. Results: Results from the simulated dataset showed that Groupwise-LLR achieved more accurate tracking and strain estimation compared with the other methods. Results from the in vivo dataset showed that Groupwise-LLR achieved more accurate tracking and elimination of the drift effect in late-diastole. Inter-observer reproducibility of strain estimates was similar between all studied methods. Conclusion: The proposed method estimates myocardial strains more accurately due to the application of a groupwise registration-based tracking strategy and an LLR-based dissimilarity metric. Significance: The proposed CMR-FT method may facilitate more accurate estimation of myocardial strains, especially in diastole, for clinical assessments of cardiac dysfunction

Numerical modeling on the seismic responses of a large underground structure in soft ground

To estimate the earthquake damages of a large subway station built in soft ground, a soil-underground structure static and dynamic coupling interaction model is advanced with the strong nonlinear properties of soil modeled by a developed viscous-plastic constitutive model. The numerical modeling results show that the large underground structure in soft site has a large vertical relative deformation during the horizontal earthquake, which could be larger than its horizontal relative deformation. The dynamic deformation responses of the components near to the middle span of the underground structure are obviously larger those of the other components at the side spans, which means that these components near to the middle span are more apt to be damaged in horizontal earthquake. According to the horizontal relative deformation and the seismic damage process of the large underground structure, which limited elastic working state and the limited elastic-plastic working state are determined, and the maximal interlayer displacement angles are suggested to be 1/430 for the limited elastic working state and 1/185 for the limited elastic-plastic working state. In addition, the seismic soil pressure coefficients on the upper side wall have significant changes. To the large underground structure shown in this paper, the seismic soil pressure coefficients on the top half of the upper side wall should be defined alone in its seismic design